Captain David Farragut leaves Hampton Roads aboard the USS Hartford en route to assume command of military operations on the southern Mississippi River
Union Brigadier General Charles Stone arrested and taken to Fort Lafayette, New York and placed in solitary confinement. He was not told the reason for his confinement
Navy Secretary Gideon Welles forms an organization to review inventions and technical developments. The group eventually became today's National Academy of Science
Jefferson Davis is inaugurated as the first (and only) President of the Confederate States of America. Alexander Stephens is inaugurated Vice President.
"Bull" Nelson enters Nashville, Tennessee, first Confederate state capital to fall into Union hands. Don Carlos Buell accepts the city's surrender. Nathan Bedford Forrest provides a rear guard for Hardee's Army of Central Kentucky as it withdraws to Alabama.
After withdrawing from New Madrid Confederates control Island No. 10, blocking shipping on the Mississippi. Over 5,000 Confederate soldiers on the island surrender to Major General John Pope on April 8.